姓名:崔晋龙
职称:教授
联系方式:CJL717@sxu.edu.cn
介绍:
崔晋龙,博士,山西大学应用化学研究所&中医药现代研究中心教授,博导。毕业于清华大学&北京协和医学院,美国俄亥俄州立大学(Ohio State University)访问学者。兼任中国民族医药学会常务理事、山西省科协首席科学传播专家、山西省微生物学会常务理事、山西省药理学会代谢组学分会常务理事等。主持国家自然科学基金面上项目3项,教育部博士点基金、山西省留学回国基金、山西省自然科学基金等10余项。获得授权软著1项、国家发明专利8项;以第一作者或通讯作者在Microbiol. Res.、Crit. Rev. Plant Sci.、Ind. Crop. Prod.、J. Sci. Food Agr.、J. Agric. Food Chem.、药学学报等发表文章约80篇,被New Phytol., Fungal Divers., Microorga.等引用1200次。参编著作《新编中药材学》(黄璐琦主编)、《绿药觅踪》(肖培根主编)二部。现主要从事内生真菌对中药品质的调控与质量控制、中草药化学与代谢组学、药食两用真菌资源发现与开发等。
2008/09-2011/07,清华大学&北京协和医学院,生药学,医学博士
2005/09-2008/07,首都师范大学,生命科学学院,微生物学,硕士
1997/09-2001/07,山西大学,生命科学学院,生物化学,理学学士
学习与工作经历:
2019/5-至今,山西大学,中医药现代研究中心,博士生导师
2011/7-2018.12,山西大学,应用化学研究所,教授
2015/10-2016/11,美国俄亥俄州立大学(The Ohio State University)访问学者
2001/07-2005/09,太原工业学院,生物工程系,生化制药教研室主任
2008/09-2011/07,清华大学&北京协和医学院,生药学,医学博士
2005/09-2008/07,首都师范大学,生命科学学院,微生物学,硕士
1997/09-2001/07,山西大学,生命科学学院,生物化学,理学学士
研究方向:
内生真菌对药用植物品质的调控与质量控制、中草药化学与代谢组学、药食两用真菌资源发现与开发等。
硕士招生专业:
本草生物学、药学、中药学(分子生物学、药物化学、微生物学等优先)
主持科研项目:
1、国家自然科学基金面上项目(32470419):内生真菌对草麻黄茎与根差异代谢物积累的影响机理,50万,2025.01-2028.12。
2、中央本级重大增减支项目:名贵中药资源可持续利用能力建设项目(2060302),20万,2023.7.1-2025.12.31。
3、山西省基础研究计划(20210302123428):内生菌对草麻黄代谢物质形成的生物学活性,10.00万元,2022.01-2024.12,主持。
4、国家自然科学基金面上项目(31670328):锁阳-白刺寄生发育的内生真菌生态演替及与锁阳代谢的关联性研究, 61万,2017.01-2020.12。
5、山西省2022年度留学人员科技活动择优资助项目(20220004):晋北特有植物麻黄内生真菌分子特征及其对宿主品质的影响,5.00万元,2022.1-2024.12。
6、山西省留学回国基金(2020-013):内生真菌对晋产道地黄芪品质的影响,4万,2020.8.1-2023.7.31。
7、国家自然科学基金面上项目(31270383):内生真菌对红景天活性成分积累的影响规律及机制研究,76万,2013.1-2016.12。
8、山西省自然科学基金项目(2014011029-1):红景天内生真菌遗传特征及抗氧化功能专属关系,3万, 2014.1-2016.12。
9、高等学校博士学科点专项科研基金资助课题(201214011 20001):内生真菌诱导红景天活性成分积累的规律及机制研究,4万,2013.1-2015.12。
10、山西大学博士科研启动项目(20110401):红景天内生真菌及其生物转化体系的建立,6万,2011.07-2012.07。
11、山西省研究生教育改革课题(2019JG018):交叉学科中导师团队协同培养创新型研究生体系的探索与构建,2万,2019.6-2021.6。
代表性论文:
1. Ding-Hui Feng, Jin-Long Cui*. The effect of endophytic fungus CA3-A with biotransformation or catalysis activity on the metabolite formation of traditional Chinese medicinal Astragalus membranaceus var. mongholicus (Bunge) P. K. Hsiao. Plant Foods Hum Nutr., 2025, 80(1):69.
2. Shan Jiang, Jin-Long Cui*. miRNA‑TF‑gene regulatory network in metabolite differentiation of stem and root parts in Ephedra sinica Stapf. Plant Growth Regul., 2025: https://doi.org/10.1007/s10725-025-01286-7.
3. Xiao Xing Wei, Hai-Xia Zhao, Jin-Long Cui*. Endophyte is an effective supplement to traditional factors affecting plant seed germination and its mechanism research progress. Russ. J. Plant Physiol., 2025, 72(2): publishing.
4. Ding-Hui Feng, Jin-Long Cui*. Progress on metabolites of Astragalus medicinal plants and a new factor affecting their formation: Biotransformation of endophytic fungi. Arch. Pharm. 2024; e2400249.
5. Xiao-Ke Li, Xue-Mei Qin, Jin-Long Cui*. Transcriptional regulatory mechanisms of flavonoid metabolism from flower bud to flower in Hemerocallis citrina. Sci. Hortic. 2024, 326: 112766.
6. Xi Liu, Jin-Long Cui*, Zhong-Ya Zhou, Zong-Bao Zhang, Xuan-Ge Cui, Bo Han, Jun-Hong Wang, Meng-Liang Wang, Yi-Min Li*.“Mini-community” simulation revealed the differences of endophytic fungal communities between the above- and below-ground tissues of Ephedra sinica Stapf. Fungal Biol., 2023, 127:1276-1283.
7. Hui Zhang, Ye Xia, Jin-Long Cui*, Xin Ji, Shuang-Man Miao, Gang Zhang, Yi-Min Li. The composition characteristics of endophytic communities and their relationship with metabolites profile in Ephedra sinica under wild and cultivated conditions. Environ. Sci. Pollut. R., 2023, 30: 95648-95659.
8. Xiao-Ke Li, Jin-Long Cui*, Xue-Mei Qin, Jun-Hong Wang, Meng-Liang Wang. Metabolic and transcriptional regulatory mechanisms of differential carbohydrates formation from flower buds to flowers of Hemerocallis citrina. Sci. Hortic. 2023, 308:111553.
9. Shuang-Man Miao, Ye Xia, Jin-Long Cui*,Jun-Hong Wang,Meng-Liang Wang. Correlation analysis between differential metabolites and endophytes of Ephedra sinica in different years. Ind. Crop. Prod. 2022,175: 114250.
10. Xin Ji, Ye Xia, Hui Zhang, Jin-Long Cui*. The microscopic mechanism between endophytic fungi and host plants: From recognition to building stable mutually beneficial relationships. Microbiol. Res. 2022, 261(127056):1-11.
11. Zhang-Xuan Guo#, Xiao-Ke Li#, Jin-Long Cui*, Shuang-Man Miao, Meng-Liang Wang, Jun-Hong Wang, Muhammad Danial.Transcriptional regulatory mechanism of differential metabolite formation in root and stem of Ephedra sinica. Appl. Biochem. Biotech. 2022, 194: 5506-5521.
12. Zhong-Ya Zhou, Xi Liu, Jin-Long Cui*, Jun-Hong Wang, Meng-Liang Wang, Gang Zhang*. Endophytic fungi and their bioactive secondary metabolites in medicinal leguminosae plants: nearly untapped medical resource. FEMS Microbiol. Lett. 2022, 369(1):1-14.
13. Shan Jiang, Jin-Long Cui*, Xiao-ke Li. MicroRNA-mediated gene regulation of secondary metabolism in medicinal plants. Crit. Rev. Plant Sci. 2021, 40(6): 459-478.
14. Xiaoke Li, Shan Jiang, Jinlong Cui*, Xuemei Qin,Gang Zhang. Progress of genus Hemerocallis in traditional uses, phytochemistry, and pharmacology. J. Hortic. Sci. Biotech. 2022, 97(3):298-314.
15. Xi Liu, Zhong-Ya Zhou, Jin-Long Cui*, Meng-Liang Wang, Jun-Hong Wang. Biotransformation ability of endophytic fungi: from species evolution to industrial applications. Appl. Microbiol. Biot. 2021, 105: 7095-7113.
16. Shuang-Man Miao#, Yan-Yan Zhang#, Jin-Long Cui*, Gang Zhang*. Species and geographic specificity between endophytic fungi and host supported by parasitic Cynomorium songaricum and its host Nitraria tangutorum distributed in desert. Arch. Microbiol., 2021, Doi: 10.1007/s0 0203-021-02224-7.
17. Xiao-zan Xue, Qi Zhang, Xiao-bao Bi, Yi Gong, Meng-liang Wang, Jun-hong Wang, Jin-long Cui*. NMR and UPLC-QTOF/MS-based metabolomics of different developmental stages of Cynomorium songaricum. Ital. J. Food Sci., 2020, 32: 997-1017.
18. Jin-Long Cui*, Xiao-Yin Gao, Vinod Vijayakumar, Zhang-Xuan Guo, Meng-Liang Wang*, Jun-Hong Wanga and Lei Liu. Regulation of fungal endophyte on Rhodiola crenulata from enzyme genes to metabolites based on combination of transcriptome and metabolome. J. Sci. Food Agr., 2020, 100: 4483–4494.
19. Qi Zhang, Xiao-Zan Xue, Shuang-Man Miao, Jin-Long Cui*, Xue-Mei Qin. Differential relationship of fungal endophytic communities and metabolic profiling between stems and roots from Ephedra sinica based on metagenomics and metabolomics. Symbiosis. 2020, 81(2):115-125.
20. Shuang-Man Miao, Qi Zhang, Xiao-bao Bi, Jin-Long Cui*, Meng-Liang Wang, Jun-Hong Wang. A review of the phytochemistry and pharmacological activities of Ephedra herb. Chin. J. Nat. Med. 2020, 18(5): 1-24.
21. Jin-Long Cui, Yi Gong, Vinod Vijayakumar, Gang Zhang, Meng-Liang Wang, Jun-Hong Wang and Xiao-Zan Xue. Correlation in chemical metabolome and endophytic mycobiome in Cynomorium songaricum from different desert locations in China. J. Agric. Food Chem. 2019, 67(13): 3554-3564.
22. Jin-Long Cui, Yan-Yan Zhang, Vinod Vijayakumar, Gang Zhang, Meng-Liang Wang, Jun-Hong Wang. Secondary metabolite accumulation associates with ecological succession of endophytic fungi in Cynomorium songaricum. J. Agric. Food Chem. 2018, 66(22):5499-5509.
23. Jin-Long Cui, Vinod Vijayakumar, Gan Zhang. Partitioning of fungal endophyte assemblages in root-parasitic plant Cynomorium songaricum and its host Nitraria tangutorum. Front. Microbiol., 2018, 9:666.
24. Jin-Long Cui, Yi Gong, Xiao-Zan Xue, Meng-Liang Wang, Junhong Wang. A phytochemical and pharmacological review on Cynomorium songaricum Rupr. as functional and medicinal food. Nat. prod. Commun, 2018,13(4):501-510.
25. Jin-Long Cui, Ya-Nan Wang, Jin Jiao, Yi Gong, Jun-Hong Wang, Meng-Liang Wang*. Fungal endophyte-induced salidroside and tyrosol biosynthesis combined with signal cross-talk and the mechanism of enzyme gene expression in Rhodiola crenulata. Sci. Rep., 2017, 7: 12540 DOI:10.1038/s41598-017-12895-2.
26. Jin-Long Cui, Tingting Guo, Jianbin Chao, Mengliang Wang, Junhong Wang. Potential of the Endophytic fungus Phialocephala fortinii Rac56 found in Rhodiola plants to produce salidroside and p-Tyrosol. Molecules. 2016, 21(4), 502; doi:10.3390/molecules21040502
27. Jin-Long Cui, Tingting Guo, Zhenxing Ren, Nasha Zhang, Mengliang Wang. Diversity and antioxidant activity of culturable endophytic fungi from alpine plants of Rhodiola crenulata, R. angusta, and R. sachalinensis. Plos one. 2015, 10(3):e0118204.doi:10.1371/journal. pone.0118204.
28. Jin-Long Cui, Li Fan*,Shaobin Fu,Mengliang Wang,Nasha Zhang,Tingting Guo. Inhibiting the growth of pathogenic microorganisms and producing flavonoids from endophytic fungi associated with Scutellaria baicalensis. Minerva. Biotecnol., 2014, 26(4): 215-221.
29. Jin-Long Cui, ChunLan Wang, ShunXing Guo *, PeiGen Xiaoa, MengLiang Wang. Stimulation of dragon’s blood accumulation in Dracaena cambodiana via fungal inoculation. Fitoterapia, 2013, 87: 31-36.
30. Jin-Long Cui, Chunlan Wang, Shunxing Guo, Lin Yang, Peigen Xiao, Mengliang Wang. Evaluation of fungus-induced agilawood from Aquilaria sinensis in China. Symbiosis, 2013, 60: 37-44.
31. Jin-Long Cui, ShunXing Guo*, Shaobin Fu, PeiGen Xiao, Mengliang Wang. Effects of inoculating fungi on agilawood formation in Aquilaria sinensis. Chinese Sci. Bull., 2013, 58(26): 3280-3287
32. Jin-Long Cui, ShunXing Guo*, PeiGen Xiao. Antitumor and antimicrobial activities of endophytic fungi from the medicinal parts of Aquilaria sinensis. J. zhejiang Univ. sci. B., 2011,12(5): 385-392.
33. Jin-Long Cui, Shunxing Guo*, Hailing Dong, Peigen Xiao. Endophytic fungi from dragon′s blood specimen: isolation, identification, phylogenetic diversity and bioactivity. Phytother. Res., 2011, 25:1189-1195.
34. Jin-Long Cui, Yunqiang Wang, Yongmei Xing, Shunxing Guo, Peigen Xiao, Mengliang Wang. Antimicrobial activity of endophytic fungi isolated from Dendrobium species in Southwestern China. Chin. J. Chin. Mater. Med., 2012, 37(6): 764-770.
35. Shaobin Fu, Junshan Yang, Jinlong Cui, Di-an Sun Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity. Fitoterapia. 2013,86:123-128.
36. Yongmei Xing, Juan Chen, Jinlong Cui, Shunxing Guo*. Antimicrobial activity and biodiversity of endophytic fungi in Dendrobium devonianum and Dendrobium thyrsiflorum from Vietman. Curr. Microbiol., 2011.62:1218-1224.
37. Yali Lv, Fusheng Zhang, Juan Chen, Jinlong Cui, Yongmei Xing, Xiangdong Li, and Shunxing Guo*. Diversity and antimicrobial activity of endophytic fungi associated with the alpine plant Saussurea involucrata. Biol. Pharm. Bull., 2010, 33(8): 1300-1306.
38. Shaobin Fu, Junshan Yang, Jinlong Cui, Xu Feng, Di-an Sun*. Microbial transformation of Ursolic acid by an endophytic fungus isolated from Huperzia serrata. Chem. Pharm. Bull., 2011, 59(9): 1180-1182.
39. Shaobin Fu, Junshan Yang, Jinlong Cui, Qingfeng Meng, Xu Feng. Dian Sun. Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata. Fitoterapia, 2011, 82(7): 1057-1061.
40. Xiaoming Tan, Xiaomen Chen, Chunlan Wang, Xiaohua Jin, Jinlong Cui, Juan Chen, Shunxing Guo*, Lifang Zhao. Isolation and identification of endophytic fungi from roots of nine Holcoglossum plants (Orchidaceae), collected in Yunnan, Guangxi and Hainan provinces of China. Curr. Microbiol., 2012, 64(2):140-147.
41.崔晋龙, 范黎* ,丁翠 ,王玉君. 栽培黄芩高活性内生真菌菌株的筛选与鉴定,西北植物学报,2007,27(7):1384-1388.
42. 崔晋龙,郭吉刚,范黎*. 远志内生真菌分离鉴定及活性筛选,微生物学通报,2007,34(5):839-842.
43. 崔晋龙,丁翠,付晓燕,范黎*. 棉花种子的品种鉴定及方法探讨,棉花学报,2006,18(5):319-320.
44. 崔晋龙, 刘磊,王玉君,丁翠,姜鹏,范 黎*. 发酵条件对菌株SBM7抑菌活性的影响,首都师范大学学报,2008,29(4):42-45.
45. 丁翠,崔晋龙,刘磊,范黎*. 羊肚菌菌核及营养型研究现状,食用菌,2008,20(2):1-4.
46. 王玉君,崔晋龙,苏红,范黎*. 远志内生真菌活性筛选,微生物学通报,2009,36(3):404-411.
47. 李青连,苏红,池维丹,崔晋龙,范黎*. 野生黄芩内生真菌的分离鉴定及抗菌活性筛选,微生物学通报, 2010, 37(3): 381-388.
48. 崔晋龙,郭顺星*,肖培根. 沉香结香部位内生真菌的多样性和生物活性评价, 2010年全国博士生学术论坛(生物医学工程),主办单位:北京大学研究生院, 2010.8.8,pp40-43.
49. 付少彬,杨峻山,崔晋龙,孙迪安*,药用植物内生菌对乌苏酸的微生物转化筛选。中国药学杂志,2011,46(16):1225-1228.
50. 崔晋龙,肖培根,郭顺星,王梦亮. 筛选诱导白木香产生沉香的真菌的研究.中国药学杂志,2012, 47(5): 335-338.
51. 崔晋龙,付少彬,高芬,王梦亮*.真菌诱导植物次生代谢产物积累的信号机制及在药用植物中的应用. 中草药,2012,43(8):1647-1651.
52. 崔晋龙,肖培根,郭顺星,王梦亮.诱导白木香产生沉香真菌的固体培养条件优化. 中国药学杂志,2012,47(17): 1357-1361.
53. 崔晋龙,肖培根,郭顺星. 真菌诱导白木香产生沉香的野外试验与分析. 中国药学杂志,2012,47(20):1614-1616.
54. 崔晋龙,付少彬,王梦亮. 红景天苷生物、化学和生物催化合成的分子理论及应用. 天然产物研究与开发,2013,25(6):851-855.
55. 王梦亮,姜骉麟,崔晋龙,焦红卫. 表面活性剂在水-有机两相体系中对β-葡萄糖苷酶催化合成红景天苷的影响. 分子催化, 2013, 27(1): 1-6.
56. 崔晋龙,肖培根,郭顺星,王梦亮. 3株诱导白木香结香真菌基本特性的评价.中国药学杂志,2013, 48(20):1711-1714.
57. 王梦亮,张娜莎,郭婷,崔晋龙*.植物生长物质对大花红景天愈伤组织诱导及苗再生的影响.植物生理学报,2014,50(2):192-196.
58. 崔晋龙,郭婷婷,王俊宏,王梦亮。一株柴胡红景天中内生真菌的抗氧化活性.食品科学. 2015.36(17): 22-27.
59. 王梦亮,郭婷婷, 张娜莎, 崔晋龙*. 2株长白红景天内生真菌的鉴定及抗氧化活性条件的优化. 天然产物研究与开发, 2015, 27(4): 67-673.
60. 崔晋龙,郭婷婷,王梦亮. 三种红景天总黄酮类物质的抗氧化活性的比较分析. 中国科技论文在线精品论文, 2015, 8(17): 1802-1808.
61. 崔晋龙,任晓琳,王梦亮*. 2 个产地红景天 rDNA-ITS 序列及亲缘关系分析. 药物分析杂志,2015,35(10): 14-18.
62. 王梦亮,闫舒雅,崔晋龙*,王俊宏, ZPRs-S-12的抑菌活性评价及发酵条件优化。山西大学学报,2015,38(1):155-159.
63. 崔晋龙,郭婷婷,王梦亮,王俊宏,任振兴. 长白红景天内生真菌抗氧化活性的评价. 中国科技论文在线精品论文, 2015, 9(5): 491-497.
64. 王梦亮,王雅楠,崔晋龙*,王俊宏:内生真菌对大花红景天中红景天苷合成代谢途径中关键酶表达的影响.药学学报,2016, 51(12): 1920-1925.
65. 王梦亮,焦晋,邢婕,田俊生,崔晋龙*,王俊宏. 内生真菌ZPRa-R-1对红景天中关键信号分子及主要次生代谢物的影响. 植物研究,2016, 36(3):416-420.
66. 崔晋龙,郭婷婷,王梦亮. 高效液相色谱法测定大花红景天野生与组培品种中5种主要活性成分,中国药学杂志,2016, 51(3):67-70.
67. 王梦亮,任晓琳,崔晋龙*,王俊宏. 野生红景天的RAPD和ISSR遗传多样性分析. 中草药. 2016, 47(3):469-473.
68. 王梦亮,贾岩,崔晋龙*,王俊宏. 锁阳及其寄主白刺内生真菌的生态分布及遗传关系. 应用生态学报, 2017, 28(3): 815-820.
69. 崔晋龙,郭顺星,肖培根.内生菌与植物的互作关系及对药用植物的影响.药学学报,2017, 52 (2): 214−221.
70. 崔晋龙,任晓琳,王梦亮*.ISSR分子标记内生真菌胁迫大花红景天条件下遗传特征分析。山西大学学报, 2017, 40(1):155-159
71. 王梦亮,张艳艳,贾岩,崔晋龙*,王俊宏。ITS2条形码序列对药用植物锁阳和白刺的鉴定. 中国现代中药,2017, 19(11): 1532-1536
72. 崔晋龙,任晓琳,王梦亮*. 内生真菌与大花红景天互作的RAPD标记分析. 微生物学杂志, 2017, 37(5): 8-12.
73. 王梦亮,高小音,崔晋龙*,王俊宏. 内生菌Phialocephala fortinii影响大花红景天代谢的差异途径及基因表达. 药学学报,2018, 53(12): 2122-2128.
74. 高小音, 王梦亮, 崔晋龙*, 王俊红, 郭岩军, 刘 雷. “组学”在内生菌与植物互作研究中的应用. 微生物前沿, 2019, 8(2), 51-60.
75. 张慧,纪鑫,崔晋龙*,秦雪梅. 锁阳和唐古特白刺寄生体内生细菌生态特征及功能研究.山西大学学报, 2022,45(6): 1634-1641.
授权专利:
1. 崔晋龙,李晓科,秦雪梅.黄花菜中黄酮的提取方法和提取装置. 授权公告日: 2022.4.5,专利号:ZL202110989600.5.
2. 崔晋龙,张艳艳.利用真菌促进锁阳种子萌发的方法. 授权公告日: 2020.9.29, 专利号:201710842009.0
3. 崔晋龙,王雅楠,王梦亮. 双内参基因检测红景天苷合成酶基因表达活性的方法. 授权公告日:2019.6.28,专利号:CN201610316147.0
4. 崔晋龙,焦晋,王梦亮. 促进大花红景天积累红景天苷的真菌菌株及其应用。国家发明专利,授权公告日:2018.8.8,专利号:ZL 201610011872.7
5. 崔晋龙,王梦亮. 提高红景天组培苗中红景天苷和酪醇含量的方法。国家发明专利,授权时间:2016.9.28,专利号:ZL 201410468041.3
6. 崔晋龙,王梦亮. 利用红松头霉菌生产红景天苷和酪醇的方法. 国家发明专利,授权公告日:2017.4.26,专利号:ZL201410720396.7
7. 郭顺星,崔晋龙,陈晓梅,王春兰,孟志霞. 诱导龙血树产生血竭的2株真菌,国家发明专利,授权时间:2013.5.29,专利号:ZL 201110044300.6.
8. 郭顺星,崔晋龙,陈晓梅,王春兰,孟志霞. 诱导白木香产生沉香的3株真菌,国家发明专利,授权时间:2013.8.28,专利号:ZL 201110044325.6
授权著作与软著:
1.蒋珊,崔晋龙,蒋成. 叶绿体基因分析软件V1.0(cpDNAAP),计算机软件著作,中国版权保护中心登记号:2022SR0218422.证书号:9172621.批准时间:2022.2.11。
2.《绿药觅踪》肖培根等,中国医药科技出版社,2011.
3.《新编中国药材学》(第三卷)黄璐琦,屠鹏飞等,中国医药科技出版社,2020.